PRECLINICAL | CONFERENCE ABSTRACT
Ashwagandha-Derived Exosome-Like Nanoparticles Promote Human Hair Growth Ex Vivo
The aim of this study was to determine the effect of Ashwagandha Exosomes on hair growth in ex vivo human hair follicles.
Intervention: Ashwagandha Exosomes (a source of plant-derived protein, RNA and lipids) were applied to female and male micro-dissected human hair follicles ex vivo.
Methods: Hair cycle staging and hair shaft production was assessed via immunohistomorphometry, which enables structural characterization of the follicles. RNA sequencing analysis was also performed to identify signaling pathways impacted by treatment with the Ashwagandha Exosomes.
Key Findings
1
At the end of the culture, a significant increase in the number of anagen (actively growing) hair follicles was observed. Hair shaft production was also increased.
2
An upregulation of anagen-promoting RNAs and a downregulation of catagen (transition phase)-inducing RNAs was also observed.
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