CLINICAL TRIAL | PEER-REVIEWED PUBLICATION

1

Hair counts:

a) Nutrafol Women's Vegan significantly increased the number of terminal hairs after 90 and 180 days of treatment, relative to baseline: from 138.6 ± 37.2 to 159.3 ± 43.9 hairs per cm² (P<0.01). This translates to a 15% increase in terminal hairs.

b) Total hair counts were also significantly increased following treatment with Nutrafol Women’s Vegan, from 150.1 ± 35.8 at baseline to 169.2 ± 42.8 hairs per cm² at day 180 (P<0.01), translating to a 12.8% increase at Day 180.

c) Vellus hairs significantly decreased, from 11.5 at baseline to 9.9 hairs per cm² at day 180 (P<0.01). Furthermore, a significant increase in the terminal-to-vellus hair ratio was observed at Day 90 (P<0.05) and Day 180 (P<0.01). Average hair width was also significantly increased at Day 90 and Day 180 (P<0.01 at both timepoints).

Changes in hair parameters. Top: Vellus, terminal and total hair counts; Bottom, left: Terminal-to-vellus hair ratio; Bottom; right: Average hair width. * P<0.05 and ** P<0.01, compared to baseline. Adapted from Sivamani et al., A Prospective, Multi-Center Study to Evaluate the Safety and Efficacy of a Vegan Nutraceutical to Improve Hair Growth and Quality in Females Following a Plant-Based Diet. Journal of Drugs in Dermatology (2024), 23(8):661-668.

2

Hair shedding was evaluated in four different regions of the scalp: vertex, occipital, right parietal and left parietal areas. Total hair shed combined from all regions progressively and significantly decreased throughout the study following Nutrafol Women’s Vegan treatment, from 2.0 ± 2.3 at baseline to 1.4 ± 1.5 at Day 90 and 1.0 ± 1.3 at Day 180 (P<0.01 at both timepoints relative to baseline). Closer examination of the data revealed that the right and left parietal areas of the scalp both exhibited significant reductions in shedding (P<0.01 for both regions at Day 180, relative to baseline). Meanwhile, the vertex and occipital areas did not display significant reductions.

Changes in hair shedding. Left: Results from all combined regions. Right: Results from four individual regions. * P<0.05 and ** P<0.01, compared to baseline. Adapted from Sivamani et al., A Prospective, Multi-Center Study to Evaluate the Safety and Efficacy of a Vegan Nutraceutical to Improve Hair Growth and Quality in Females Following a Plant-Based Diet. Journal of Drugs in Dermatology (2024), 23(8):661-668.

3

Results from the subjective questionnaires revealed improvements in hair parameters and quality of life. Notably, 82% of subjects reported improvements in hair strength, and 85% of subjects reported improvements in overall hair quality, after 180 days of treatment.

Subjective assessment of changes in hair parameters. *Indicates a significant proportion of subjects reporting a favorable response compared with the proportion of subjects reporting an unfavorable response (P<0.01).

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Finally, Nutrafol Women’s Vegan was well tolerated with no serious adverse events.